Marianna Fontana Selected Research

NTLA-2001

1/2021

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis.

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Marianna Fontana Research Topics

Disease

88	Amyloidosis 05/2024 - 05/2013
37	Immunoglobulin Light-chain Amyloidosis 01/2024 - 01/2013
30	Cardiomyopathies (Cardiomyopathy) 04/2024 - 06/2012
23	Heart Failure 05/2024 - 05/2007
16	Transthyretin-Related Hereditary Amyloidosis 11/2023 - 02/2014
11	Aortic Valve Stenosis (Aortic Stenosis) 01/2022 - 12/2012
9	COVID-19 01/2023 - 12/2020
8	Infections 01/2023 - 01/2021
8	Amyloid Plaque 12/2022 - 09/2015
8	ST Elevation Myocardial Infarction 10/2021 - 01/2015
6	Polyneuropathies (Polyneuropathy) 03/2024 - 01/2021
5	Hypertrophy 01/2023 - 03/2015
5	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2020 - 12/2012
4	Disease Progression 05/2024 - 11/2007
4	Myocardial Infarction 04/2024 - 09/2013
4	Cicatrix (Scar) 01/2023 - 11/2017
3	Paraproteinemias (Monoclonal Gammopathy) 01/2023 - 01/2021
3	Chronic Kidney Failure (Chronic Renal Failure) 12/2022 - 12/2015
3	Fibrosis (Cirrhosis) 01/2022 - 01/2018
3	Infarction (Infarctions) 01/2021 - 09/2013
3	Fabry Disease (Fabry's Disease) 01/2020 - 05/2013
3	Edema (Dropsy) 01/2020 - 08/2017
3	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 12/2014 - 04/2013
2	Hypoxia (Hypoxemia) 01/2024 - 06/2011
2	Chronic Renal Insufficiency 11/2023 - 01/2023
2	Convalescence 01/2023 - 01/2021
2	Proteinuria 01/2022 - 01/2019
2	Atrial Fibrillation 01/2022 - 01/2022
2	Coronary Disease (Coronary Heart Disease) 01/2022 - 01/2021
2	Ventricular Remodeling 01/2021 - 10/2016
2	Myocarditis (Carditis) 01/2021 - 12/2019
2	Restrictive Cardiomyopathy 01/2020 - 01/2018
2	Neoplasm Metastasis (Metastasis) 01/2020 - 09/2019
2	Hypertension (High Blood Pressure) 09/2017 - 05/2013
2	Hemorrhage 01/2017 - 10/2016
2	Death (Near-Death Experience) 07/2011 - 02/2009
2	Left Ventricular Dysfunction 07/2011 - 01/2008
2	Cardiovascular Diseases (Cardiovascular Disease) 07/2011 - 01/2008
1	Hyponatremia 02/2024
1	Hyperbilirubinemia 02/2024
1	Hypoalbuminemia 02/2024
1	Anemia 02/2024
1	Albuminuria 11/2023
1	Body Weight (Weight, Body) 10/2023
1	Spasm (Spasms) 10/2023

Drug/Important Bio-Agent (IBA)

68	Amyloid (Amyloid Fibrils)IBA 04/2024 - 12/2012
58	Prealbumin (Transthyretin)IBA 05/2024 - 10/2015
20	Biomarkers (Surrogate Marker)IBA 02/2024 - 07/2011
17	Brain Natriuretic Peptide (Natrecor)FDA Link 05/2024 - 05/2007
15	GadoliniumIBA 11/2021 - 09/2013
11	pro-brain natriuretic peptide (1-76)IBA 03/2024 - 05/2007
10	Proteins (Proteins, Gene)FDA Link 12/2022 - 06/2016
8	Troponin T (Troponin T1)IBA 02/2024 - 01/2013
7	TroponinIBA 02/2024 - 01/2020
7	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 01/2022 - 02/2017
6	patisiranIBA 10/2023 - 01/2021
4	CreatinineIBA 11/2023 - 02/2009
4	Small Interfering RNA (siRNA)IBA 03/2023 - 01/2021
4	Natriuretic PeptidesIBA 01/2023 - 11/2007
4	Radioisotopes (Radionuclides)IBA 01/2023 - 11/2019
4	AcidsIBA 01/2022 - 12/2017
4	Bortezomib (Velcade)FDA Link 04/2021 - 12/2019
3	DiureticsIBA 05/2024 - 01/2022
3	InotersenIBA 03/2023 - 10/2022
3	Messenger RNA (mRNA)IBA 01/2023 - 01/2022
3	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2023 - 12/2022
3	VaccinesIBA 01/2022 - 04/2021
3	Adenosine (Adenocard)FDA LinkGeneric 01/2021 - 10/2019
3	CollagenIBA 05/2017 - 12/2012
2	omega-Chloroacetophenone (Mace)IBA 04/2024 - 01/2020
2	Clostridium perfringens epsilon-toxinIBA 03/2024 - 10/2021
2	Technetium (Technetium 99m)IBA 02/2024 - 06/2016
2	RNA (Ribonucleic Acid)IBA 03/2023 - 10/2022
2	LipidsIBA 11/2022 - 05/2013
2	Complement System Proteins (Complement)IBA 11/2022 - 09/2015
2	BNT162 VaccineIBA 01/2022 - 04/2021
2	Immunoglobulin G (IgG)IBA 01/2022 - 09/2015
2	Neutralizing AntibodiesIBA 04/2021 - 12/2020
2	SphingolipidsIBA 01/2020 - 12/2014
2	Carboxylic AcidsIBA 01/2018 - 09/2015
2	Blood Proteins (Serum Proteins)IBA 01/2018 - 09/2015
2	Serum Amyloid P-ComponentIBA 01/2018 - 09/2015
2	pyrrolidineIBA 01/2018 - 09/2015
2	AntibodiesIBA 02/2017 - 09/2015
2	IronIBA 10/2016 - 08/2016
2	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2012 - 02/2009
1	Sodium-Glucose Transport ProteinsIBA 04/2024
1	diphosphoric acid (pyrophosphoric acid)IBA 02/2024
1	C-Reactive ProteinIBA 02/2024
1	Urea (Carbamide)FDA LinkGeneric 02/2024
1	Alkaline PhosphataseIBA 02/2024
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2024
1	AlbuminsIBA 11/2023

Therapy/Procedure

22	Therapeutics 01/2024 - 03/2015
7	Drug Therapy (Chemotherapy) 01/2023 - 05/2015
7	Percutaneous Coronary Intervention 10/2021 - 01/2015
3	Transcatheter Aortic Valve Replacement 01/2022 - 01/2018
2	Aftercare (After-Treatment) 01/2024 - 12/2018
2	Heart Transplantation (Grafting, Heart) 01/2023 - 01/2022
2	Stem Cell Transplantation 04/2021 - 12/2019